Centaurin Beta 2 (CENTb2)

The 3-prime untranslated region of the CENTB2 mRNA contains an Alu repeat. CENTB2 shares 52% sequence identity with CENTB1 and about 28% identity with ankyrin. Northern blot analysis revealed ubiquitous expression, with highest levels detected in peripheral blood leukocytes, followed by placenta, kidney, spleen, and ovary. Lowest levels were detected in brain.The deduced 778-amino acid protein contains 2 N-terminal coiled-coil regions, a pleckstrin homology (PH) domain, an ARF-GAP domain, and C-terminal ankyrin repeats. ACAP2 shares significant similarity with CENTB1, which the authors called ACAP1, and 95% identity with mouse Acap2. It also shares similarity with ASAP1 and PAP in the ARF-GAP domain and in the overall domain structure.