Centromere Protein Q (CENPQ)

CENPQ is a subunit of a CENPH-CENPI-associated centromeric complex that targets CENPA to centromeres and is required for proper kinetochore function and mitotic progression.Okada et al. (2006) identified CENPQ as a component of the CENPH-CENPI centromeric complex. They stated that deletion of CENPQ in a chicken B-cell line and in HeLa cells resulted in viable cells that grew more slowly than controls, but did not alter the centromeric of other CENPH-CENPI complex components. Since cells deficient in CENPQ were similar to those deficient in CENPO, CENPP, and CENP50 (MLF1IP), Okada et al. (2006) suggested that these proteins form an accessory subcomplex within the CENPH-CENPI centromeric complex.