Centromere Protein V (CENPV)

Cronshaw et al. (2002) identified p30 as a constituent of a purified nucleoporin fraction from rat liver nuclei. Fluorescence-tagged p30 localized within nuclei of transfected HeLa cells, with enrichment at the nuclear periphery and around the nucleolus. It did not colocalize with the nuclear pore complex. Cronshaw et al. (2002) hypothesized that p30 may link peripheral nuclear structures with the nuclear interior.The International Radiation Hybrid Mapping Consortium mapped the p30 gene to chromosome 17 . A centromere is a region of DNA typically found near the middle of a chromosome where two identical sister chromatids come in contact. It is involved in cell division as the point of mitotic spindle.