Cerebellin 3 (CBLN3)

Members of the precerebellin family, such as CBLN3, contain a cerebellin motif and a C-terminal C1q signature domain that mediates trimeric assembly of atypical collagen complexes. However, precerebellins do not contain a collagen motif, suggesting that they are not conventional components of the extracellular matrix.the cerebellin motif of Cbln3 is quite different from that of Cbln1, indicating that Cbln3 is not a cerebellin precursor. Northern blot analysis detected several Cbln1 transcripts in adult mouse cerebellum, but not in forebrain, spinal cord, or any other adult mouse tissue examined. Examination of brain samples from embryonic and young mice revealed that Cbln3 was not expressed until postnatal day 7. In situ hybridization of adult brain showed Cbln3 in the internal granule cell layer of the cerebellum and in the dorsal cochlear nucleus.