Chloride Channel Protein Kb (CLCNKB)

Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels. Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome. CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.the intron-exon organization of the CLCNKA and CLCNKB genes was identical, with each channel encoded by 19 exons. Overall, the genes show 94% DNA sequence identity in exons. The 2 genes are transcribed from the same DNA strand, with CLCNKA 5-prime of CLCNKB. The 2 genes are separated by 11 kb of genomic DNA.