Chloride Intracellular Channel Protein 2 (CLIC2)

Chloride intracellular channel protein 2 is a protein encoded by the CLIC2 gene.Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.As part of an effort to produce a transcript map of the Xq28 chromosomal region, Rogner et al. (1996) characterized a cDNA that they designated XAP121, or CLIC2. Heiss and Poustka (1997) reported that the predicted 243-amino acid CLIC2 protein shares 60% identity with the CLIC1 protein, a nuclear chloride channel.