Chromosome 11 Open Reading Frame 30 (C11orf30)

EMSY amplification in 52 (18%) of 285 high-grade papillary serous carcinomas, 4 (15%) of 27 high-grade endometrioid carcinomas, 3 (8%) of 38 clear cell carcinomas, and 3 (30%) of 10 undifferentiated carcinomas. Analysis of chromosome 11q13 amplification in ovarian cancer showed that EMSY localized to the region with the highest frequency of copy number gain.The deduced 1,322-amino acid protein has a calculated molecular mass of about 160 kD. EMSY has a unique N-terminal 80-amino acid domain that is conserved between several species, including plants. Western blot analysis indicated that endogenous EMSY in the nuclear fraction of a human osteosarcoma cell line had an apparent molecular mass above 160 kD.