Chromosome 11 Open Reading Frame 41 (C11orf41)

By searching for genes in a region of chromosome 11 associated with WAGR syndrome, Gawin et al. (1999) identified and cloned C11ORF41, which they called G2. Northern blot analysis of several human tissues detected G2 transcripts of 11 and 7.9 kb in brain only. G2 also showed brain-specific expression in adult mouse.By analysis of a PAC contig covering chromosome 11p14.1-p13, Gawin et al. (1999) mapped the C11ORF41 gene to chromosome 11p13, centromeric to the CSTF3 gene and telomeric to the CD59 gene. The syndrome subsequently became known as the WAGR syndrome. In addition to """genitourinary abnormalities,""" the """G""" in WAGR syndrome may refer to """ambiguous genitalia""" or """gonadoblastoma""".