Chromosome 15 Open Reading Frame 5 (C15orf5)

Chromosome 15 is one of the 23 pairs of chromosomes in humans. Chromosome 15 spans about 106 million base pairs and represents between 3% and 3.5% of the total DNA in cells. Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 15 likely contains between 700 and 900 genes.C15orf5, a novel human gene lacking homology to any known protein. The C15orf5 gene encodes a transcript of 1,519 nt with an ORF of 94 amino acids and a predicted protein size of 11.5 kDa. Northern blot analysis showed enhanced expression of C15orf5 in heart. C15orf5 was mapped to chromosome 15q23-q24 using the Stanford TNG4 Radiation Hybrid panel.