Chromosome 6 Open Reading Frame 25 (C6orf25)

C6orf25 is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene.The deduced 241-amino acid G6B protein contains a leader sequence; an Ig domain with 4 cysteines; 2 putative N-glycosylation sites; a transmembrane region; an intracellular, proline-rich potential SH3-binding domain; and 2 putative phosphorylated tyrosine motifs, one of which has an SH2-binding domain and the other of which is common in mitogen-activated protein kinases.