Cisplatin Resistance Associated Overexpressed Protein (CROP)

The N-terminal half of the CROP contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). Cisplatin resistance-associated overexpressed protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.The shorter variant encodes a deduced 432-amino acid protein. The N-terminal half contains cystine/histidine motifs and leucine zipper-like repeats, and the C-terminal half consists mostly of charged and polar amino acids. The longer variant contains several nonsense codons and is not translatable.