Citrate Transporter Protein, Mitochondrial (CTP)

CTP is responsible for the movement of citrate across the mitochondrial inner membrane. Southern blot analysis of both rat and human genomic DNA demonstrated the presence of multiple sequences related to the tricarboxylate transporter. Database searches using genomic sequence from the DGCR identified similarity to a rodent mitochondrial tricarboxylate transport protein in the same region where GRAIL predicted a cluster of exons. The mitochondrial tricarboxylate transporter CTP is a mitochondrial transmembrane protein and is predicted to have 6 hydrophobic membrane-spanning alpha-helices with 5 intervening hydrophilic segments.Northern blots of human adult tissue revealed abundant expression in many tissues, including liver, testis, ovary, and gut, but not in brain, skeletal muscle, or lung.