Clavesin 1 (CLVS1)

Kong et al. (2006) isolated RLBP1L1, which they designated CRALBPL, from a human brain cDNA library. The deduced 354-amino acid protein contains a conserved CRAL-TRIO domain (residues 118-279) that is 45% identical to that in cellular retinaldehyde-binding protein (CRALBP, or RLBP1). The CRAL-TRIO domain is present in members of the lipid-binding SEC14-like proteins. RT-PCR analysis of 18 human tissues showed expression of RLBP1L1 exclusively in brain. Transfection experiments with an EGFP-RLBP1L1 fusion construct in HeLa cells showed localization to the cytoplasm where the RLBP1 protein localizes.Kong et al. (2006) determined that RLBP1L1 contains 6 exons and spans about 212 kb.By sequence analysis, Kong et al. (2006) mapped the RLBP1L1 gene to chromosome 8q12.2 between D8S1225 and RH12812 STS markers.