Codanin 1 (CDAN1)

The CDAN1 gene product, codanin-1, is a putative O-glycosylated protein of 1,226 amino acids with no obvious transmembrane domains. Codanin-1 has a 150-residue N-terminal domain with sequence similarity to collagens, as well as 2 shorter segments that show weak similarities to the microtubule-associated proteins MAP1B and synapsin (SYN1). Alternative splicing produces a variant encoding a 1,103-amino acid isoform. Northern blot analysis detected a 4.7-kb CDAN1 transcript in all 8 tissues tested. Codanin-1 may be involved in nuclear envelope integrity, conceivably related to microtubule attachments. CDAN1 is the human homolog of dlt. Dlt is an evolutionarily conserved protein required for cell survival and cell cycle progression in the fly.