Coiled Coil And C2 Domain Containing Protein 2A (CC2D2A)

CC2D2A contains 3 putative coiled-coil domains, a C-terminal C2 domain, and potential CaMKII recognition sites, PKC phosphorylation sites, and 2 putative nuclear localization signals. CC2D2A shares 84.8% amino acid identity with its rodent homologs. In COS-7 cells, overexpressed CC2D2A-GFP fusion protein localized almost exclusively to the cytoplasmic fraction, despite the predicted presence of potential nuclear localization signals.The deduced protein contains 1,532 amino acids. RT-PCR detected moderate CC2D2A expression in ovary, lung, brain, liver, kidney, testis, and all specific adult brain regions examined. Low expression was detected in fetal brain and adult heart, and little to no expression was detected in fetal liver and adult skeletal muscle, pancreas, and spleen.