Coiled Coil Domain Containing Protein 101 (CCDC101)

CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A)-containing (ATAC) complex and the SPT3 (SUPT3H)-TAF9-GCN5 (KAT2A)/PCAF (KAT2B) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases.Using mass spectrometry to identify subunits of the ATAC and STAGA complexes in HeLa cells, Wang et al. (2008) identified CCDC101, which they called STAF36. STAF36 had an apparent molecular mass of 36 kD by SDS-PAGE. Hartz (2010) mapped the CCDC101 gene to chromosome 16p11.2 based on an alignment of the CCDC101 sequence with the genomic sequence (GRCh37).