Coiled Coil Domain Containing Protein 5 (CCDC5)

HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb """augmentare,""" meaning """to increase.""" The deduced 278-amino acid protein contains 3 potential coiled-coil domains and a C-terminal leucine-rich nuclear exclusion sequence. CCDC5 shares 89%, 84%, and 54% amino acid identity with cow, mouse, and frog Ccdc5, respectively. No closely related proteins were identified in Drosophila or C. elegans. Northern blot analysis detected a transcript of about 1.2 to 1.3 kb in all tissues examined, with highest abundance in pancreas, heart, liver, kidney, and muscle. Western blot analysis detected a single CCDC5 protein of about 32 kD in human, dog, and monkey cells.