Coiled Coil Domain Containing Protein 78 (CCDC78)

The Coiled-coil Domain Is the Structural Determinant for Mammalian Homologues of Drosophila Sina-mediated Degradation of Promyelocytic Leukemia Protein and Other Tripartite Motif Proteins by the Proteasome.CCDC78, The G-patch domain is a short conserved region of about 40 amino acids which occurs in a number of putative RNA-binding proteins, including tumor suppressor and DNA-damage-repair proteins, suggesting that this domain may have an RNA binding function. This domain has seven highly conserved glycines. The G-patch domain is a short conserved region occurring in a number of putative RNA-binding proteins, tumor suppressors and DNA-damage-repair proteins, This domain is found in several RNA associated proteins and has been suggested to be involved in RNA binding.