Coiled Coil Domain Containing Protein 86 (CCDC86)
Английские синонимы
CYCLON; Cytokine-induced protein with coiled-coil domain
CCDC86 encodes a deduced 360-amino acid protein with a coiled-coil domain in the C terminus and repetitive sequences, which the authors referred to as SP repeats, near the N terminus. The SP repeats are shorter in the human and rat orthologs than in mice. The protein has 3 potential bipartite nuclear localization signals. Its promoter has redundant IL3-responsive elements, which were confirmed experimentally.Ccdc86 expression was also detected in activated mouse peripheral CD4+ and CD8+ T cells. Immunoblots of HA-tagged human or mouse CCDC86 detected the protein in nuclear extracts. The nuclear localization was confirmed by microscopy, and the protein was shown to be phosphorylated.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
