Cold Shock Domain Containing Protein E1, RNA Binding (CSDE1)

RNase protection assays showed that this gene, termed UNR by them, is transcribed in the same direction as NRAS and that its 3-prime end is located only 130 bp from the transcription initiation site of NRAS. The close spatial relationship was conserved in all species from which the NRAS gene had been isolated. The UNR cDNA contained an open reading frame capable of encoding a protein of 798 amino acids. UNR transcripts were detected in mouse, rat, and human cells. Only a single copy of UNR was detected in the mouse. The gene produced multiple transcripts that differed in their 3-prime ends and apparently resulted from the differential use of multiple polyadenylation sites located in the 3-prime untranslated region of the gene. Both UNR and NRAS were expressed in all tissues examined and the 2 genes may be coordinately regulated.