Component Of Oligomeric Golgi Complex 7 (COG7)

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7.The deduced 770-amino acid COG7 protein is conserved in plants and invertebrates, but not in yeast or worms. Immunofluorescence microscopy demonstrated that COG1 (LDLB) colocalizes with COG7, as well as with COG3 and COG5, with a Golgi marker in a perinuclear distribution.