Contactin 6 (CNTN6)

CNTN6 is a neural adhesion molecule of the contactin subgroup of the immunoglobulin superfamily. The deduced 1,028-amino acid GPI-anchored membrane protein is 43% and 44% identical to F3 (CNTN1) and TAG1 (CNTN2), respectively, and 90% identical to the rat protein. It contains hydrophobic segments in the N and C termini representing, respectively, a potential signal peptide and a GPI-anchoring signal. The N terminus also possesses 6 repeats typical of a C2-type Ig-like domain, while the C terminus has 4 repeated motifs homologous to type III fibronectin repeats. Northern blot analysis revealed ubiquitous expression in brain regions of a 3.7-kb transcript, with highest levels in cerebellum, followed by thalamus and subthalamic nucleus, and lower levels in corpus callosum, caudate nucleus, and spinal cord.