Cyclin M3 (CNNM3)

Mouse Acdp3 encodes a deduced 713-amino acid protein that shares 86% identity with human ACDP3. Acdp3 contains 4 transmembrane domains, 2 CBS domains, a DUF21 domain, and a cNMP-binding domain. It also has large alanine- and leucine-rich regions. Northern blot analysis detected variable Acdp3 expression in all mouse tissues examined, with highest expression in brain, kidney, liver, and heart.The ACDP3 gene, designated CNNM3 by the HUGO Nomenclature Committee, encodes a deduced 707-amino acid protein. Northern blot analysis revealed ubiquitous expression of CNNM3. Immunofluorescence studies showed that all 4 CNMM proteins are predominantly localized in the nucleus.