Cysteine And Glycine Rich Protein 1 (CSRP1)

CSRP1 is a member of the CSRP family of genes encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in CRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation Other genes in the family include CSRP2 and CSRP3.The deduced 193-amino acid protein has 2 repeats of a domain that consists of 2 putative zinc fingers immediately followed by a glycine-rich motif containing a high proportion of aromatic and basic residues. CRP does not share regions of significant structural similarity with PRL. Northern blot and RT-PCR analyses detected CRP expression in all human nucleated tissues and cell lines examined; CRP is expressed as a 1.8-kb transcript.