DDB1 And CUL4 Associated Factor 16 (DCAF16)

DDB1 And CUL4 Associated Factor 16 (DCAF16) Interacts with DDB1 and CUL4A.May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. The CUL4-DDB1-ROC1 ubiquitin E3 ligase regulates cell-cycle progression, replication and DNA damage response.  The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the substrate receptors that dictate the specificity of this ubiquitination machinery have been largely unknown. Recent work identified a family of DDB1 and CUL4-associated factors (DCAFs) as substrate receptors, implicating a broad spectrum of cellular processes regulated by CUL4-DDB1.