DENN/MADD Domain Containing Protein 4C (DENND4C)

DENND4C (DENN/MADD domain containing 4C), also known as DENN domain-containing protein 4C, C9orf55, C9orf55B, FLJ20686, bA513M16.3 or DKFZp686I09113, is a 1,673 amino acid multi-pass membrane protein. DENND4C contains a dDENN domain, DENN domain, uDENN domain and a PPR (pentatricopeptide) repeat. As a result of alternative splicing, six DENND4C isoforms exist. The gene encoding DENND4C maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.