DEP Domain Containing Protein 1B (DEPDC1B)

DEPDC1B encodes a Rho GTPase activation protein and a putative tumor suppressor protein. RhoGAPdomain is an evolutionary conserved protein domain of GTPase activating proteins towards Rho/Rac/Cdc42-like small GTPases.DEPDC1B contains 17 different gt-ag introns. Transcription produces 9 different mRNAs, 7 alternatively spliced variants and 2 unspliced forms. There are 5 probable alternative promotors and 4 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5""" end, presence or absence of 3 cassette exons, overlapping exons with different boundaries. the gene has been proposed to participate in processes. Proteins are expected to localize in various compartments.