Defective In Sister Chromatid Cohesion 1 (DSCC1)
Английские синонимы
DCC1; Sister chromatid cohesion protein DCC1
CHTF18, CHTF8, and DSCC1 are components of an alternative replication factor C (RFC) complex that loads PCNA onto DNA during S phase of the cell cycle.DSCC1 protein contains 393 amino acids and has a calculated molecular mass of 45 kD.The deduced protein has a calculated molecular mass of 44.8 kD and has 2 regions that share a high degree of conservation with yeast Dscc1. Immunohistochemical analysis showed that CHTF18, CHTF8, and DSCC1 localized to nuclear heterochromatin in a diffuse manner and appeared less abundant in nucleoli. SDS/PAGE analysis detected DSCC1 with an apparent molecular mass of about 45 kD.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
