Deformed Epidermal Autoregulatory Factor 1 (DEAF1)

Suppressin is a 63-kD inhibitor of cell proliferation. LeBoeuf et al. (1998) cloned the cDNA encoding rat suppressin. The deduced amino acid sequence contains 2 domains with significant homology to a transcription factor in Drosophila called """deformed epidermal autoregulatory factor-1""" (DEAF1). By RT-PCR, Le Boeuf et al. (1998) found that suppressin was expressed in all rat tissues tested.LeBoeuf et al. (1998) also cloned the human suppressin cDNA sequence, which encodes a predicted 497-amino acid polypeptide.Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls.