Dendritic Cell Nuclear Protein 1 (DCNP1)

DCNP1 (dendritic cell nuclear protein-1), encoding a deduced 244-amino acid protein with a predicted molecular mass of approximately 27 kD. Northern blot analysis detected expression of DCNP1 in DCs but not in monocytes or B cells, and at a much higher level in mature than in immature DCs, indicating an upregulation of transcription during the differentiation and maturation processes of DCs.Northern blot analysis on multiple human tissues detected expression of DCNP1 in brain and skeletal muscle. Immunofluorescence analysis revealed that DCNP1 resides mainly in the nucleus, particularly on the periphery. DCNP1-positive and CD68-positive cells showed a similar localization in these tissues, but there were fewer DCNP1-positive than CD68-positive cells.