Diaphanous Homolog 2 (DIAPH2)

DIAPH2 may play a role in the development and normal function of the ovaries. The use of alternative last exons results in 2 DIAPH2 proteins that differ in their C termini: DIAPH2-156, which uses exon 156 and contains 1,101 amino acids, and DIAPH2-12C, which uses exon 12C and contains 1,096 amino acids.The sequence encoded by exon 156 is significantly similar to the comparable sequence of Drosophila dia, while the sequence encoded by exon 12C is quite different. DIAPH2-156 and Drosophila dia share about 39% amino acid identity. Both DIAPH2 isoforms contain formin homology-1 (FH1) and FH2 domains that are flanked by 2 coiled-coil domains. DIAPH2 also has a predicted nuclear localization signal near its C terminus.