Dicarboxylate Transporter, Mitochondrial (DIC)

The dicarboxylate carrier catalyzes the transport of dicarboxylates such as malate and succinate across the mitochondrial membrane in exchange for phosphate, sulfate, and thiosulfate, thus supplying substrates for the Krebs cycle, gluconeogenesis, urea synthesis, and sulfur metabolism.Human DIC encodes a deduced 287-amino acid protein, 1 amino acid longer than the rat and mouse proteins with which it shares 88% and 89% sequence identity, respectively. Expression of a 2.3-kb transcript, with highest levels in kidney and liver, intermediate levels in pancreas, lung, placenta, brain, and heart, and low levels in skeletal muscle. highest protein levels in rat mitochondrial lysates obtained from kidney and liver, lower levels in lysates from lung, spleen, heart, and brain, and lowest levels in lysates from skeletal muscle.