Discs, Large Homolog 2 (DLG2)

DLG2 encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Like PSD95 and SAP97, the predicted 870-amino acid chapsyn-110 protein contains 3 PDZ domains, an SH3 domain, and a guanylate kinase homology region. The chapsyn-110 protein is 78%, 71%, and 57% identical to SAP97, PSD95, and the Drosophila """discs large""" protein, respectively. Using immunohistochemical analysis of rat brain, these authors found that chapsyn-110 has a somatodendritic expression pattern that overlaps partly with PSD95 but that contrasts with the axonal distribution of SAP97.