Dispatched Homolog 2 (DISP2)

The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched.Ma et al. (2002) isolated cDNAs encoding 2 murine homologs of dipatched, which they called Dispa and Dispb. They predicted that the dispatched proteins all have 12 transmembrane spans with cytoplasmic N and C termini.