Downstream Neighbor Of SON (DONSON)

By large-scale sequence analysis of chromosome 21q, Slavov et al. (2000) identified DONSON, which they called B17. RT-PCR showed B17 expression in HeLa cells, 8-week fetus, 10-week fetus, fetal brain, adult brain, cerebellum, hippocampus, occipital lobe, and vermis.By sequence analysis, Slavov et al. (2000) predicted that the DONSON gene contains at least 7 exons spanning 10 kb. By genomic sequence analysis, Slavov et al. (2000) mapped the DONSON gene to chromosome 21q22.1. Wynn et al. (2000) determined that both human and mouse SON and DONSON are in tail-to-tail orientation and in the following order: GART-SON-DONSON.