E74 Like Factor 3 (ELF3)

Oettgen et al. (1997) isolated and characterized a novel member of the ETS transcription factor family , which they called ESX (also known as ESS-E). This was the first ETS factor and one of only a few transcription factors known to be exclusively expressed in epithelial cells. ESX contains 2 putative DNA-binding domains: an ETS domain and an A/T hook domain.By scanning mutagenesis, Kwon et al. (2003) identified a functional ESE1 site in the promoter region of MIP3-alpha (CCL20) expressed by Caco-2 human intestinal epithelial cells.Oettgen et al. (1999) determined that the ELF3 gene contains 9 exons spanning approximately 5.8 kb of genomic DNA.By fluorescence in situ hybridization (FISH), Oettgen et al. (1997) mapped the ESX gene to 1q32. By the same method, Tymms et al. (1997) refined the location to 1q32.2.