EF-Hand Calcium Binding Domain Protein 6 (EFCAB6)
Английские синонимы
DJBP; HSCBCIP1; DJ-1-Binding Protein; CAP-Binding Protein Complex-Interacting Protein 1
DJBP mRNA was found to be specifically expressed in the testis. In addition to the binding of DJBP to the COOH-terminal region of DJ-1, DJBP was also found to bind in vitro and in vivo to the DNA-binding domain of the AR in a testosterone-dependent manner and to be colocalized with DJ-1 or AR in the nucleus. Furthermore, a co-immunoprecipitation assay showed that the formation of a ternary complex between DJ-1, DJBP, and AR occurred in cells in which DJ-1 bound to the AR via DJBP. DJBP repressed a testosterone-dependent AR transactivation activity in monkey Cos1 cells by recruiting histone deacetylase (HDAC) complex, including HDAC1 and mSin3, and that DJ-1 partially restored its repressed activity by abrogating DJBP-HDAC complex.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
