EH Domain Containing Protein 2 (EHD2)

EHD2 encodes a member of the EH domain-containing protein family. The deduced protein identities between EHD1 and EHD2, between EHD1 and EHD3, and between EHD1 and EHD4, are 71%, 86%, and 76%, respectively. All contain multiple conserved regions, including a nucleotide-binding consensus site at the N terminus, a bipartite nuclear localization signal, and an EPS15 homology (EH) protein-binding domain with an EF-hand motif at the C terminus. EHD2 encodes a deduced 543-amino acid protein. Northern blot analysis detected a 3.6-kb EHD2 transcript that was highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle, as well as an approximately 6.0-kb transcript that was expressed at low levels in heart and skeletal muscle.