EH Domain Containing Protein 3 (EHD3)

Pohl et al. (2000) identified 3 novel genes, designated EHD2, EHD3, and EHD4, which are homologous to human EHD1. EHD3 identities between EHD1 and EHD2, between EHD1 and EHD3, and between EHD1 and EHD4, are 71%, 86%, and 76%, respectively. All contain multiple conserved regions that include a nucleotide-binding consensus site at the N terminus, a bipartite nuclear localization signal, and an eps15 homology (EH) protein-binding domain with an EF-hand motif at the C terminus. EHD3 encodes a deduced 546-amino acid protein. Northern blot analysis detected a 3.6-kb EHD3 transcript that is highly expressed in heart and brain and moderately expressed in kidney, liver, and placenta.