Epiprofin (Epfn)

SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.Mouse and human SP6 encode deduced 376-amino acid proteins that share 96% amino acid identity. Residues within each of the 3 zinc fingers that establish specific contacts with DNA are completely conserved in SP6, suggesting that mouse and human SP6 recognize a classical GC box. RT-PCR analysis revealed SP6 expression in all mouse tissues examined.endogenous epiprofin expressed by primary mouse dental epithelial cells and epiprofin expressed by transfected COS-7 cells promoted cell proliferation.