Erythrocyte Membrane Protein Band 4.1 Like Protein 1 (EPB41L1)

Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. EPB41L1 is a neuronally-enriched protein that is structurally similar to EPB41. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them has been determined.The 6,263-bp cDNA contains an open reading frame encoding 934 amino acids; it may lack 5-prime coding sequence. The predicted polypeptide is 46% identical to EPB41 across 670 amino acids. By SDS-PAGE, the in vitro transcribed/translated product of the cDNA had a molecular mass of greater than 100 kD.