F-Box And Leucine Rich Repeat Protein 12 (FBXL12)

Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.Winston et al. (1999) cloned mouse Fbl12. The deduced protein contains an N-terminal F box, followed by 7 tandem leucine-rich repeats.Jin et al. (2004) reported that the human FBXL12 protein contains an N-terminal F box, followed by 7 leucine-rich repeats.Jin et al. (2004) stated that the FBXL12 gene maps to chromosome 19p13.2 and the mouse Fbxl12 gene maps to chromosome 9A3.