F-Box And Leucine Rich Repeat Protein 13 (FBXL13)

Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.The human FBXL13 protein contains an N-terminal F box, followed by a tandem array of 4 leucine-rich repeats, a short spacer, and a second tandem array of 7 leucine-rich repeats.A message of about 1.6 kb encodes a protein with an F-box domain and 5 leucine-rich repeats, and a message of about 2.3 kb encodes a protein with an F-box domain and 12 leucine-rich repeats.