F-Box And Leucine Rich Repeat Protein 22 (FBXL22)

Members of the F-box protein family, such as FBXL22, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin , and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains .Jin et al. (2004) reported that the FBXL22 protein contains an F-box in its N-terminal half and 3 tandem leucine-rich repeats in its C-terminal half.Jin et al. (2004) stated that the FBXL22 gene maps to chromosome 15q22.1 and the mouse Fbxl22 gene maps to chromosome 9C.