F-Box Protein 10 (FBXO10)

Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.Jin et al. (2004) reported that the FBXO10 protein contains a central F box and a C-terminal CASH domain, which is found in carbohydrate-binding proteins and sugar hydrolases.Jin et al. (2004) stated that the FBXO10 gene maps to chromosome 9p13.1 and the mouse Fbxo10 gene maps to chromosome 4B1.