F-Box Protein 17 (FBXO17)

Members of the F-box protein family, such as FBXO17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.The deduced protein contains 278 amino acids. Northern blot analysis detected a 2.4-kb transcript highly expressed in kidney. Lower expression was detected in liver, and little to no expression was detected in all other tissues examined.The deduced protein contains an N-terminal F box, followed by an F box-associated domain.