F-Box Protein 38 (FBXO38)

The deduced 1,193-amino acid protein has a calculated molecular mass of about 140 kD. It contains an N-terminal F-box domain, followed by 3 nuclear export signals (NES) and 3 C-terminal nuclear localization signals. Moka also has a highly acidic stretch of about 100 amino acids, an asp-rich stretch, and a ser-rich stretch. In situ hybridization found Moka and Klf7 coexpressed in the developing mouse nervous system and in adult testis.Overexpression in COS-7 cells indicated that Moka is posttranslationally modified, since the apparent molecular mass was greater than 140 kD. Fluorescence-tagged Moka localized to both the nuclear and cytosolic compartments of transfected COS-7 cells and mouse fibroblasts.