F-Box Protein 42 (FBXO42)

Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.The deduced protein contains at least 651 amino acids. RT-PCR ELISA detected intermediate expression in adult brain, testis, ovary, liver, and kidney, low expression in heart and fetal brain, and little to no expression in all other tissues examined. Low to intermediate expression was detected in all specific brain regions examined, with highest expression in amygdala and caudate nucleus.