F-Box Protein 46 (FBXO46)

Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.By exon trapping and screening a brain cDNA library, Alwazzan et al. (1998) cloned FBXO46, which they designated 20D7. The deduced protein contains 202 amino acids. Northern blot analysis of 6 rat tissues detected a 2.3-kb transcript only in testis.Jin et al. (2004) reported that the FBXO46 protein contains a C-terminal F box, followed by a CHORD zinc-binding domain.