FCH And Double SH3 Domains Protein 2 (FCHSD2)
Английские синонимы
SH3MD3; Carom; SH3 Multiple Domains 3; F-BAR and double SH3 domains protein 2
FCHSD1 and FCHSD2 genes with conserved exon-intron structure were located at human chromosome 5q31.3 and 11q13.4, respectively. Human FCHSD1 (690 aa) showed 41.7% total-amino-acid identity with human FCHSD2 (740 aa), and 91.0% total-amino-acid identity with mouse Fchsd1. Human FCHSD2 showed 96.5% total-amino-acid identity with mouse Fchsd2. Mammalian FCHSD family proteins shared the common domain structure consisting of FCH, FBH, two SH3 and C-terminal Proline-rich domains. FCHSD family proteins (FCHSD1 and FCHSD2), FNBP1 family proteins (FNBP1, FNBP1L and TRIP10/CIP4) and FNBP2 family proteins (FNBP2, ARHGAP13/SRGAP1, ARHGAP14/SRGAP2 and ARHGAP4) were found constituting the FCFBS superfamily characterized by FCH, FBH and SH3 domains.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
